7-Keto Dhea – The Science Of Weight Loss
Dietary ingredients targeting weight loss are commonly thrust into the media spotlight. This year, television personality Dr. Oz enthusiastically endorsed the ingredient 7-keto-DHEA, evoking overnight popularity, sensational headlines, and skyrocketing sales.
Claims about weight loss products rank notoriously high on the FDA and FTC radar. Thus, it is extremely important to assess whether current research on these ingredients lives up to media hype, do they actual work, and more importantly has their safety been properly assessed.
DHEA is the most abundant adrenal steroid in young adults, peaking at ages 20 to 25 and markedly decreasing in middle age. Its overall decline is associated with many age-related conditions.
The ingredient 7-keto-DHEA (7-keto-dehydroepiandrosterone or 7-oxo-dehydroepiandrosterone) is a metabolite of dehydroepiandrosterone(DHEA), an endogenous human
hormone produced by the adrenal glands.
It is important to understand that 7-Keto DHEA does not have any hormonal effects. Many consumers get confused thinking that 7-Keto will have some kind of hormonal boosting effect, but studies by The patent holders
Humanetics have clearly shown that it does not affect the hormone profile in the human body.
Despite the science it didn’t stop the World Anti Doping Authority (WADA) from adding 7-Keto to their banned substances list. Co-incidentally this was just prior to the London Olympic games and has been referred to as a “Knee-jerk” reaction to put a blanket over any kind of supplement that may enhance performance. One can only think the decision makers saw the word “DHEA” and concluded it was the same thing! Fair enough it’s great to be pro-active but when you throw scientific proof out of the window and instead replace it with a spontaneous decision based on a quick “clean-up” prior to a sporting event it really makes one think – what next? Creatine or Protein powder – as both can increase performance! We believe Humanetics is working to get 7-Keto DHEA removed from the WADA banned list and rightfully so as it should have never been added in the first place.
Facts on DHEA
Supplemental DHEA has been associated with prolonging life span and beneficially altering body weight, composition, and dietary energy utilization. (DHEA, however, is a precursor to other steroid hormones, such as testosterone and estrogen. Therefore, its widespread use has been somewhat limited due to the potential negative effects of enhanced steroidal hormone production.) It is now thought that DHEA may exert these antiaging effects by way of its biologically active metabolites 7-keto-DHEA without any effect on the fore-mentioned hormonal pathways. Yes indeed hormones do play a role in slowing down the aging process but there is a lot more to the equation, including the ability to maintain a healthy lifestyle and keeping body fat under control.
The Thermogenic Effect of 7-Keto Dhea
Thermogenic and anti-adipogenic effects of 7-keto-DHEA and its metabolites have been identified, although are not fully understood. These compounds are thought to stimulate thermogenesis by enhancing mitochondrial function, similarly to thyroid hormone. Likewise, 7-keto-DHEA has demonstrated the ability to enhance the production of thermogenic enzymes within liver cells, including G-3-P dehydrogenase and malic enzyme. Fatty acid oxidation may also be enhanced by 7-keto-DHEA, as suggested by an increase in fatty acyl-CoA oxidase activities in animals after ingesting 7-keto DHEA.
To read the full article on 7-Keto Dhea The Science of Weight Loss purchase volume 6 issue 4 of Australian Natural Bodz Magazine link.